English name:        Prilocaine
CAS Number:         721-50-6
Molecular formula:  C13H20N2O
Molecular weight:    220.31
EINECS number:    211-957-0

Melting point:     37-38°
Boiling point:      bp0.1159-162°
Density:             1.0117(roughestimate)
Solubility:           Slightlysolubleinwater, verysoluChemicalbookbleinacetoneandinethanol(96percent).
Water solubility: 6.169g/L(25ºC)

Uses:local anesthetics. This product has better efficacy than procaine. The intensity and speed of local anesthesia are similar to lidocaine, but the action time is longer, the toxicity is less, and the metabolism is faster, and the accumulation is less. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.

Local anesthetics:Prilocaine is an amide local anesthetic. Its intensity and speed are similar to lidocaine, but it lasts longer and has a weaker effect on vasodilation. The toxicity is lower than that of lidoca. It is clinically used for local anesthesia, especially for patients who are not allowed to use epinephrine. [Pharmacology] The local anesthetic effect of its 3% solution is equivalent to that of 2% lidocaine plus epinephrine. Chemicalbook has a slower onset, about 6 to 7 minutes, and a maintenance time of about 1.5 to 2 hours. It has strong mucosal penetration. Adrenaline slightly prolongs its action time. PPB is 55%, T1/2 is about 1.5h. Metabolism in the liver, its metabolite nitrosotoluidine can oxidize hemoglobin to form methemoglobin. Can be transported to the fetus through the placenta.

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