English name:           Levobupivacaine hydrochloride
CAS Number:            27262-48-2
Molecular formula:    C18H29ClN2O
Molecular weight:      324.89
EINECS number:      1308068-626-2
Melting point:            254 °C (dec.)(lit.)
Specific rotation:       -12.5 º (c=2, water)
Storage conditions:   2-8°C
Solubility: H2O:         soluble20mg/mL, clear

Uses: Levobupivacaine is an amide local anesthetic.

In vitro studies: Levobupivacaine is an amide-type local anesthetic. Levobupivacaine works by blocking voltage-sensitive ion channels in neuronal cell membranes to prevent the conduction of nerve impulses. By interfering with the opening of sodium channels, a locally reversible anesthetic effect is produced, which inhibits the conduction of nerve action potentials including sensory, motor activity and sympathetic nerve activity.

In vivo study: Levobupivacaine and bupivacaine have similar nerve blocking efficacy. Levobupivacaine inhibited motor muscle and pain response at a dose of 0.125%, with the maximum %MPE of 99 and 68, respectively, and inhibited the duration of sciatic nerve block lagging motor muscle and pain response (60 and 30, respectively).